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Publications and Patents


Izzetoglu M, Du J, Dor BB, inventors; Drexel University, assignee. Non-invasive brain water monitoring device for cerebral edema and cerebral autoregulation monitoring system and method. United States patent US 10,499,838. 2019 Dec 10.

Izzetoglu K., Izzetoglu M. "Functional near-infrared spectroscopy as a monitor for depth of anesthesia." U.S. Patent 9,955,901, issued May 1, 2018

Severino L., Tecce DeCarlo M.J., Izzetoglu M., Peluso A., Miller S., Otti O. "System and Method for Evaluating Reading Comprehension." U.S. Patent Application 14/884,802, filed April 21, 2016, Pending.

Izzetoglu, K., Pourrezaei K., Onaral B., Horrow C.J., Izzetoglu M., Bunce S.C. "Functional near-infrared spectroscopy as a monitor for depth of anesthesia." U.S. Patent 8,798,701, issued August 5, 2014.

Scott B.C., Devaraj A., Izzetoglu M.A., Onaral B., Izzetoglu K., Pourrezaei K. "Deception detection and query methodology for determining deception via neuroimaging." U.S. Patent 8,346,331, issued January 1, 2013.

Journal Publications:

Izzetoglu M, Shewokis P, Tsai K, Dantoin P, Sparango K, Min K. Short-Term Effects of Meditation on Sustained Attention as Measured by fNIRS. Brain Sciences. 2020 August 25.

Altınkaynak M, Dolu N, Guven A, Pektas F, Ozmen S, Demirci E, Izzetoglu M. Diagnosis of Attention Deficit Hyperactivity Disorder with combined time and frequency features. Biocybernetics and Biomedical Engineering. 2020 May 4.

Izzetoglu M, Du J, Izzetoglu K, Ayaz H, Onaral B, Dor BB. Multi-layer, Dynamic, Mixed Solid/Liquid Human Head Models for the Evaluation of Near Infrared Spectroscopy Systems. IEEE Transactions on Instrumentation and Measurement. 2020 Apr 24.

Izzetoglu M, Holtzer R. Effects of Processing Methods on fNIRS Signals Assessed During Active Walking Tasks in Older Adults. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2020 Feb 12;28(3):699-709.

Wang L, Ayaz H, Izzetoglu M. Investigation of the source‐detector separation in near infrared spectroscopy for healthy and clinical applications. Journal of Biophotonics. 2019 Nov;12(11): e201900175.

Guven A, Altınkaynak M, Dolu N, Izzetoglu M, Pektas F, Ozmen S, Demirci E, Batbat T. Combining functional near-infrared spectroscopy and EEG measurements for the diagnosis of attention-deficit hyperactivity disorder. Neural Computing and Applications. 2019 Jul 3:1-4.

Wagshul ME, Lucas M, Ye K, Izzetoglu M, Holtzer R. Multi-modal neuroimaging of dual-task walking: Structural MRI and fNIRS analysis reveals prefrontal grey matter volume moderation of brain activation in older adults. NeuroImage. 2019 Apr 1;189:745-54.

Guven A, Altinkaynak M, Dolu N, Demirci E, Ozmen S, Izzetoglu M, Pektas F. Effects of methylphenidate on reaction time in children with attention deficit/hyperactivity disorder. Archives of Neuropsychiatry. 2019 Mar;56(1):27.

Holtzer R, Kraut R, Izzetoglu M, Ye K. The effect of fear of falling on prefrontal cortex activation and efficiency during walking in older adults. GeroScience. 2019 Feb 15;41(1):89-100.

Ayaz H, Izzetoglu M, Izzetoglu K, Onaral B, Dor BB. Early diagnosis of traumatic intracranial hematomas. Journal of biomedical optics. 2019 Feb;24(5):051411.

Holtzer R, Lucas M, Wagshul M, Izzetoglu M. White Matter Integrity Moderates the Efficiency of Prefrontal Cortex Activation Patterns During Walking. Innovation in Aging. 2018.

EDITOR'S CHOICE: M. Lucas, M. Wagshul, M. Izzetoglu,R. Holtzer. "Monitoring Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults." The Journal of Gerontology, March 2019.

Hernandez ME, O’Donnell E, Chaparro G, Holtzer R, Izzetoglu M, Sandroff BM, Motl RW. Brain activation changes during balance-and attention-demanding tasks in middle-and older-aged adults with multiple sclerosis. Motor control. 2019
C. George, J. Verghese, M. Izzetoglu, C. Wang, R. Holtzer. “The effect of Polypharmacy on Prefrontal Cortex Activation during Single and Dual Task Walking in Community Dwelling Older Adults.” Pharmacological Research, 2018.

M. Altinkaynak, N. Dolu, A Guven, S. Aktas, E. Demirci, M. Izzetoglu, F Pektas. “Effects of Methylphenidate Treatment in Children With ADHD: A Multimodal EEG/fNIRS Approach." Psychiatry and Clinical Psychopharmacology. 2018.

L. Severino, MJ Tecce DeCarlo, T. Sondergeld, M. Izzetoglu, A. Ammar. “A Validation Study of a Middle Grades Reading Comprehension Assessment.” Research in Middle Level Evaluation, 41(10):1-16. 2018.

Holtzer R, Izzetoglu M, Chen M, Wang C. Distinct fNIRS-Derived HbO2 Trajectories During the Course and Over Repeated Walking Trials Under Single-and Dual-Task Conditions: Implications for Within Session Learning and Prefrontal Cortex Efficiency in Older Adults. The Journals of Gerontology: Series A. 2019.

M. Lucas, M.E. Wagshul, M. Izzetoglu, R. Holtzer. “Moderating Effect of White Matter Integrity on Brain Activation During Dual-Task Walking in Older Adults.” The Journals of Gerontology: Series A. 2018.

R. Holtzer, CJ George, M. Izzetoglu, C. Wang, “The effect of diabetes on prefrontal cortex activation patterns during active walking in older adults,” Brain and Cognition, 2018.

S.N. Malaeb, M. Izzetoglu, J. McGowan, M. Delivoria-Papadopoulos, “Noninvasive monitoring of brain edema after hypoxia in newborn piglets,” Pediatric research.2017

M. Chen, S. Pillemer, S. England, M. Izzetoglu, JR. Mahoney, R. Holtzer, “Neural Correlates of Obstacle Negotiation in Older Adults: An fNIRS Study,” Gait & Posture. 2017 Jul 18.

G. Chaparro, JM. Balto, BM. Sandroff, R. Holtzer, M. Izzetoglu, RW. Motl, ME. Hernandez, “Frontal brain activation changes due to dual-tasking under partial body weight support conditions in older adults with multiple sclerosis,” J. of NeuroEngineering and Rehabilitation, June 2017.

G. Hernandez-Meza, M. Izzetoglu, A. Sacan, M. Green, K. Izzetoglu, “Investigation of data-driven optical neuromonitoring approach during general anesthesia with sevoflurane,” Neurophotonics. Aug;4(4):041408, 2017.

L. Wang, H. Ayaz, M. Izzetoglu, B. Onaral, “Evaluation of light detector surface area for functional Near Infrared Spectroscopy,” Computers in Biology and Medicine. 2017.

G. Hernandez-Meza, M. Izzetoglu, M. Osbakken, M. Green, H. Abubakar, K. Izzetoglu, “Investigation of optical neuro-monitoring technique for detection of maintenance and emergence states during general anesthesia,” Journal of Clinical Monitoring and Computing, 1-17, 2017.

M. Chen, HM. Blumen, M. Izzetoglu, R. Holtzer, "Spatial co-registration of functional near-infrared spectroscopy to brain MRI," Journal of Neuroimaging, 2017.

R. Holtzer, C. Scheon, E. Demetriou, J.R. Mahoney, M. Izzetoglu, C. Wang, J. Verghese, “Stress and gender effects on prefrontal cortex oxygenation levels assessed during single and dual-task walking conditions,” European Journal of Neuroscience, 2016.

M.E.Hernandez, R. Holtzer, G. Chaparro, K. Jean, J.M. Balto, B.M. Sandroff, M. Izzetoglu, R.W. Motl, “Brain activation changes during locomotion in middle-aged to older adults with multiple sclerosis,” Journal of Neurological Sciences; 370: 277-83, 2016.

J. Verghese, C. Wang, E Ayers, M. Izzetoglu, R. Holtzer, “Brain activation patterns in high functioning older adults and risk of falls: prospective cohort study,” Neurology, 2016

R. Holtzer, J Yuan, J. Verghese, J.R. Mahoney, M. Izzetoglu, C. Wang, “Interactions of Subjective and Objective Measures of Fatigue Defined in the Context of Brain Control of Locomotion”, J Gerontol A Biol Sci Med Sci, 1–7, 2016.

L.H. Glassman, A.T. Kuster, J.A. Shaw, E.M. Forman, M. Izzetoglu, A. Matteucci, J.D. Herbert, “The relationship between dorsolateral prefrontal activation and speech performance-based social anxiety using functional near infrared spectroscopy,” Brain Imaging and Behavior, 1-11, 2016.

J.R. Mahoney, R. Holtzer, M. Izzetoglu, V. Zemon, J. Verghese, G. Allali, “The role of prefrontal cortex during postural control in Parkinsonian syndromes a functional near-infrared spectroscopy study,” Brain research, 633:126-38, 2016.

L.H. Glassman, E.M. Forman, J.D. Herbert, L.E. Bradley, E.E. Foster, M. Izzetoglu, A.C. Ruocco, “The effects of a brief acceptance-based behavioral treatment vs. traditional cognitive-behavioral treatment for public speaking anxiety: Differential effects on performance and neurophysiology,” Behavior Modification, 0145445516629939, 2016.

R. Holtzer, J.R. Mahoney, M. Izzetoglu, C. Wang, S. England, J. Verghese, “Neurological Gait Abnormalities Moderate the Functional Brain Signature of the Posture First Hypothesis”, Brain Topography, 1-10, 2015.

R. Holtzer, J.R. Mahoney, M. Izzetoglu, C. Wang, S. England, J. Verghese, “Online Fronto-cortical Control Of Simple and Attention-Demanding Locomotion in Humans”, Neuroimage, 112:152-159, 2015

G. Hernandez-Meza, M. Izzetoglu, M. Osbakken, M. Green, K. Izzetoglu, “Near-Infrared Spectroscopy for the Evaluation of Anesthetic Depth,” BioMed Research International, vol. 11, 2015.

L.H. Glassman, J.D. Herbert, E.M. Forman, L.E. Bradley, M. Izzetoglu, A.C. Ruocco, S.P. Goldstein, "Near-infrared spectroscopic assessment of in-vivo prefrontal activation in public speaking anxiety: A preliminary investigation,"  Psychology of Consciousness: Theory, Research, and Practice, 1(3), 271-283, 2014.

A.C.R. Merzagora, M. Izzetoglu, B. Onaral, M.T. Schultheis, “Verbal working memory impairments following traumatic brain injury: an fNIRS investigation,” Brain imaging and behavior, 1-14, 2013.

U. Leon-Dominguez, M. Izzetoglu, J. Leon-Carrion, F.J.G. Torrado, A.F. Rogriguez, P.M.Miras, D.V.Duque, J.L.LRomero, B. Onaral, K. Izzetoglu, “Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness,” Neuroimage, 85:616-625, 2013.

A. Curtin, K. Izzetoglu, J. Reynolds, R. Menon, M. Izzetoglu, M. Osbakken, B. Onaral, “Functional near-infrared spectroscopy for the measurement of propofol effects in conscious sedation during outpatient elective colonoscopy,” Neuroimage, 1: 626-636, 2013.

Bunce, S.C., Harris, J., Izzetoglu, K., Ayaz, H., Izzetoglu, M., Pourrezaei, K., Onaral, B., “Functional Near-Infrared Spectroscopy in Addiction Treatment: Preliminary Evidence as a Biomarker of Treatment Response,” In D. Schmorrow & C. Fidopiastis (Eds.), Foundations of Augmented Cognition (Vol. 8027, pp. 250-258): Springer Berlin Heidelberg, 2013.

Books and Book Chapters:

  1. H. Ayaz, M. Izzetoglu, H. Izzetoglu, B. Onaral, “Functional Near Infrared Spectroscopy for Neuroergonomics,” Neuroergonomics, The Brain at Work and in Everyday Life, 1st Edition, Editors: Hasan Ayaz, Frederic Dehais, 2018
  2. M. Izzetoglu, "Functional Optical Brain Imaging " Biomedical Engineering Handbook, 4th Edition, Editor in Chief: Joseph D. Bronzino,

A complete and most current list of Dr. Izzetoglu’s publications can be found on Google Scholar.


Dr. Meltem Izzetoglu

Dr. Meltem Izzetoglu
Electrical and Computer Engineering