Dr. William Kelly has expertise in scale up and bioprocessing of cell culture products, and has extensive experience working with pharmaceutical companies to improve manufacturing processes and practices.
Title: Biomanufacturing: Optimizing the Isolation, Transfection, and Expansion of CAR-T cells with Modified PES Membranes
Sponsor: National Science Foundation
Start Date: 2016
Investigators: Dr. Jacob Elmer (PI) with Drs. Noelle Comolli and William Kelly (co-PIs)
Description: In this collaborative research project, Dr. Elmer is using novel non-viral methods to optimize T-cell transfection, Dr. Comolli is working on novel surface modified membranes for T-cell selection and activation, and Dr. Kelly is optimizing the expansion of the specific T-cell subsets.
NovaCell researcher Dr. Jens Karlsson, professor of Mechanical Engineering, co-authored “FTIR Analysis of Molecular Changes Associated with Warming Injury in Cryopreserved Leukocytes” with Mian Wang and Alptekin Aksan(2019). The article appeared in Langmuir, 35(23), 7552-7559.
Villanova’s College of Engineering has introduced a Cellular Engineering course in response to industry demand. The course is taught by Dr. Jake Elmer.
Jens O. M. Karlsson co-authored “FTIR Analysis of Molecular Changes Associated with Warming Injury in Cryopreserved Leukocytes” in Langmuir, Nov. 6, 2018.
PhD student Brooks Hopkins, advised by Dr. Zuyi Huang, presented “A Model-Based Investigation of Cytokine Storm for T-Cell Therapy” during the Computational Methods in Biological and Biomedical Systems section of the 2018 AIChE Annual Meeting.
Devon Zimmerman ’18 PhD, Krupa Patel ’18 MSBChE, Matthew Hall ’19 ChE and Jacob Elmer published “Enhancement of transgene expression by nuclear transcription factor Y and CCCTC-binding factor” in Biotechnology Progress, Oct. 7, 2018.
PhD student Matthew Tucker, advised by Dr. Jacob Elmer, presented “Transcriptome (mRNA & small RNA) Analysis of the Host Cell Response to Non-Viral Gene Delivery” at the Biologics I: Drug Delivery Session of the 2018 AIChE Annual Meeting.