Biochemical Engineering Research and Facilities

Biochemical Engineering Research

Ongoing research areas for faculty in Biochemical Engineering:

  • Alternating tangential flow system optimization
  • Thin film delivery of anti-inflammatory agents
  • Nano/Micro particle design for drug delivery
  • Design and delivery of gene therapy vehicles
  • Characterization of thin film nanomaterials
  • T-cell activation and production
  • Optimization of microbioreactors
  • CHO cell metabolism
  • Pathogens in biofilms
  • Development of blood substitutes
Biochemical Engineering Research
Biochemical Engineering Research




Recent Faculty Publications


K. Lee, N. Comolli, W.J. Kelly, Z. Huang. MATLAB Based Teaching Modules in Biochemical Engineering. Chemical Engineering Education, 49(2), 95-100, 2015.

Dr. William Kelly - Biochemical Engineering and BioProcessing Laboratory

W. Kelly, J. Scully, D. Zhang, G. Feng M. Lavengood,  J. Condon, J. Knighton and R. Bhatia “Understanding and Modeling Alternating Tangential Flow Filtration for Perfusion Cell Culture”  Biotechnology Progress  DOI:10.1002/btpr.1953.

Dr. Zuyi Huang - Biological & Environmental Systems Engineering Laboratory

Q. Ping, C. Zhang, X. Chen, B. Zhang, Z. Huang, Z. He. “A Mathematic Model of Dynamic Behavior of Microbial Desalination Cells.” Environmental Science & Technology, 48, No. 21, pp. 13010–13019, 2014.

Z. Xu, X. Fang, T.K. Wood, Z. Huang. “A Systems-Level Approach for Investigating Pseudomonas aeruginosa Biofilm Formation.” PLoS One, 8(2): e57050, 2013.

Dr. Jacob Elmer - Gene Therapy and Blood Substitutes Laboratory

D. Zimmerman, J. Dienes, O. Abdulmalik, J. Elmer. “Purification of Diverse Hemoglobins by Metal Salt Precipitation.” Protein Expression Purification. 2015 Sep 9. pii: S1046-5928(15)30056-5. doi: 10.1016/j.pep.2015.09.006.

M. Christensen, J. Elmer, S. Eaton, L. Gonzalez-Malerva, J. LaBaer, K. Rege.  “Kinome-level screening identifies inhibition of polo-like kinase-1 (PLK1) as a target for enhancing non-viral transgene expression.” Journal of Controlled Release. 2015 Apr 28; 204:20-9. doi: 10.1016/j.jconrel.2015.01.036.

Dr. Noelle Comolli - Biomaterials and Drug Delivery Laboratory

O. Donaldson, Z. Huang, N. Comolli. “An integrated experimental and modeling approach to propose biotinylated PLGA microparticles as versatile targeting vehicles for drug delivery.” Progress in Biomaterials 2013, 2:3