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Biomedical Engineering Group

Publications

 

Journal Publications

  1. Z. Huang, Y. Chu, and J. Hahn. Computing Transcription Factor Distribution Profiles from Green Fluorescent Protein Reporter Data. Chemical Engineering Science , in Press, 2011
  2. Y. Chu, Z. Huang, and J. Hahn. Global Sensitivity Analysis Procedure Accounting for Effect of Available Experimental Data . Industrial & Engineering Chemistry Research 50, No. 3, pp. 1294-1304, 2011
  3. C. Moya*, Z. Huang*, P. Cheng, A. Jayaraman, and J. Hahn. Investigation of IL-6 and IL-10 Signaling in Steatosis via Mathematical Modeling. IET Systems Biology, 5, No. 1, pp. 15-26, 2011 (*equal contribution)
  4. Z. Huang*, C. Moya*, J. Hahn, and A. Jayaraman. Using the Tet-On System to Develop a Procedure for Extracting Transcription Factor Activation Dynamics. Molecular Biosystems 6, pp. 1883-1889, 2010 (*equal contribution)
  5. Z. Huang, Y. Chu, B. Cunha, and J. Hahn. Generalization of a Procedure for Computing Transcription Factor Profiles. IET Systems Biology 4, No. 2, pp. 108-118, 2010
  6. R. Kaunas, Z. Huang, and J. Hahn. A Kinematic Model Coupling Stress Fiber Dynamics with JNK Activation in Response to Matrix Stretching. Journal of Theoretical Biology 264, No.2, pp. 593-603, 2010
  7. Z. Huang, Y. Chu, and J. Hahn. Model Simplification Procedure for Signal Transduction Pathway Models: An Application to IL-6 Signaling. Chemical Engineering Science 65, No.6, pp. 1964-1975, 2010
  8. Z. Huang and J. Hahn. Fuzzy Modeling of Signal Transduction Networks. Chemical Engineering Science 64, No. 9, pp. 2044-2056, 2009
  9. Y. Chu, Z. Huang, and J. Hahn. Improving Prediction Capabilities of Complex Dynamic Models via Parameter Selection and Estimation. Chemical Engineering Science 64, No.19, pp. 4178-4185, 2009
  10. Z. Huang, F. Senocak, A. Jayaraman, and J. Hahn. Integrated Modeling and Experimental Approach for Determining Transcription Factor Concentrations from Fluorescent Reporter Profiles. BMC Systems Biology, 2 (64), 2008
  11. J. Brewer, Z. Huang, A.K. Singh, M. Misra, and J. Hahn. Sensor Network Design via Observability Analysis and Principal Component Analysis. Industrial Engineering Chemistry Research 46, No.24, pp. 8026-8032, 2007

 

Conference Proceedings

  1. Z. Huang, Y. Chu, and J. Hahn. Derivation of Simplified Signal Transduction Pathway Models: Application to IL-6 Signaling. Proceedings of the 2010 American Control Conference, Baltimore, Maryland, pp. 5131-5136 (Invited Presentation)
  2. Z. Huang, C. Moya, P. Cheng, A. Jayaraman, and J. Hahn. In Silico Investigation of IL-6 and IL-10 Signaling in Steatosis. Proceedings Foundations of Systems Biology in Engineering 2009 (FOSBE 2009), Denver, Colorado, pp. 28-31
  3. Z. Huang, Y. Chu, and J. Hahn. Derivation of a Reduced IL-6 Signal Transduction Model. Proceedings Foundations of Systems Biology in Engineering 2009 (FOSBE 2009), Denver, Colorado, pp. 32-35
  4. Z. Huang, F. Senocak, A. Jayaraman, and J. Hahn. Solution of Inverse Problems for Obtaining Protein Concentrations from Fluorescent Microscopy Images. Proceedings of the 2009 American Control Conference (ACC 2009), St. Louis, Missouri, pp. 1688-1693
  5. Z. Huang and J. Hahn, Fuzzy Modeling of Signal Transduction Networks. Proceedings of the 2008 IFAC World Congress, Seoul, Korea, pp. 15867-15872 (Invited Presentation)
  6. Z. Huang, Y. Chu, F. Senocak, A. Jayaraman, and J. Hahn, Model Update of Signal Transduction Pathways in Hepatocytes based upon Sensitivity Analysis. Proceedings Foundations of Systems Biology 2007 (FOSBE 2007), Stuttgart, Germany, pp. 45-50 (Plenary Presentation)

 

Presentations

  1. R. Kaunas, Z. Huang, and J. Hahn. Derivation of a Kinematic Model Coupling Stress Fiber Dynamics with JNK Activation In Response to Matrix Stretching. AIChE 2011 Annual Meeting, Minneapolis, MN
  2. Z. Huang, Y. Chu, L. Bansal, and J. Hahn, Derivation of Transcription Factor Distribution Profiles From Green Fluorescent Protein Reporter Data. AIChE 2010 Annual Meeting, Salt Lake City, Utah (Invited Presentation)
  3. Y. Chu, Z. Huang, M. Serpas, and J. Hahn, Global Sensitivity Analysis Procedure Accounting for Effect of Available Experimental Data. AIChE 2010 Annual Meeting, Salt Lake City, Utah
  4. C. Moya, Z. Huang, J. Hahn, and A. Jayaraman. Quantitative Determination of Transcription Factor Profiles From Reporter Data. AIChE 2010 Annual Meeting, Salt Lake City, Utah
  5. Z. Huang, C. Moya, P. Cheng, A. Jayaraman, and J. Hahn. Mathematical Modeling of IL-6 and IL-10 Signal Transduction in Steatosis. AIChE 2009 Annual Meeting, Nashville, Tennessee
  6. Z. Huang, Y. Chu, and J. Hahn. Derivation of Reduced Models for Signal Transduction Pathways Via Sensitivity and Observability Analysis. AIChE 2009 Annual Meeting, Nashville, Tennessee
  7. Z. Huang, F. Senocak, A. Jayaraman, and J. Hahn,Quantitative Measurement Technique for Transcription Factor Profiles. AIChE 2008 Annual Meeting, Philadelphia, Pennsylvania
  8. Y. Chu, Z. Huang, and J. Hahn. Analysis Procedure for Signal Transduction Pathways by Clustering Parameters According to their Sensitivity Profiles. AIChE 2008 Annual Meeting, Philadelphia, Pennsylvania
  9. Y. Chu, Z. Huang, and J. Hahn. Sensitivity Analysis for Parameter Estimation of Signal Transduction Networks. SIAM Conference on the Life Sciences, Montreal, Canada (Invited Presentation)
  10. Z. Huang and J. Hahn. Development and Comparison of Algorithms for Analysis of Fluorescent Images for Studying the Dynamics of Signal Transduction Pathways. AIChE 2007 Annual Meeting, Salt Lake City, Utah