Faculty & Student Publications

The faculty members forming the Biochemistry Program at Villanova University are a community of scholars.  In many cases below, the publications reflect collaboration between our faculty and Villanova students.   Villanova faculty members are in bold and underlined,  Villanova undergraduate coauthors (including BS/MS students) are in red, and Villanova graduate coauthors are in blue. 

Recent Publications:

2014

Nassif ND, Cambray SE, & Kraut DA (2014) Slipping up: partial substrate degradation by ATP-dependent proteases. IUBMB life 66(5):309-317.

Fuxreiter, M, Toth-Petroczy, A, Kraut, DA, Matouschek, AT, Lim, R, Xue, B, Kurgan, L, & Uversky, V. N. (2014) Disordered Proteinaceous Machines. Chemical reviews.

Desmond ME, Knepper, JE, DiBenedetto, AJ, Malaugh, E, Callejo, S, Carretero, R, Alonso, MI, Gato, A. (2014) Focal adhesion kinase as a mechanotransducer during rapid brain growth of the chick embryo. The International journal of developmental biology 58(1):35-43.

2013

Kraut DA (2013) Slippery substrates impair ATP-dependent protease function by slowing unfolding. The Journal of biological chemistry 288(48):34729-34735.

Crabbe, A, Nielsen-Preiss, SM, Woolley, CM, Barrila, J, Buchanan, K, McCracken, J., Inglis, D. O., Searles, S. C., Nelman-Gonzalez, M. A., Ott, C. M., Wilson, JW, Pierson, DL, Stefanyshyn-Piper, HM, Hyman, LE. & Nickerson, CA. (2013) Spaceflight enhances cell aggregation and random budding in Candida albicans. PloS one 8(12):e80677.

Cangelosi C, Shank C, Santiago C, & Wilson JW (2013) Engineering large functional plasmids for biosafety. Plasmid 70(3):385-392.

Corrigan MW, Kerwin-Iosue CL, Kuczmarski AS, Amin KB, & Wykoff DD (2013) The Fate of Linear DNA in Saccharomyces cerevisiae and Candida glabrata: The Role of Homologous and Non-Homologous End Joining. PloS one 8(7):e69628.

Jacobs J, Grum-Tokars V, Zhou Y, Turlington M, Saldanha SA, Chase P, Eggler A, Dawson ES, Baez-Santos YM, Tomar S, Mielech AM, Baker SC, Lindsley CW, Hodder P, Mesecar A, & Stauffer SR (2013) Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. Journal of medicinal chemistry 56(2):534-546.

Tessema TD, Gassler F, Shu Y, Jones S, & Selinsky BS (2013) Structure-activity relationships in aminosterol antibiotics: the effect of stereochemistry at the 7-OH group. Bioorganic & medicinal chemistry letters 23(11):3377-3381.

Wilson, J.W., C.P. Santiago, J. Serfecz, and L.N. Quick. 2013. Recombineering and conjugation as tools for targeted genomic cloning. In "Genetic Manipulation of DNA and Protein - Examples from Current Research", ed. Dr. David Figurski, InTech Publishing. 

2012

Carter-O'Connell I, Peel MT, Wykoff DD, & O'Shea EK (2012) Genome-wide characterization of the phosphate starvation response in Schizosaccharomyces pombe. BMC genomics 13:697.

Comber JD & Bamezai AK (2012) In vitro derivation of interferon-gamma producing, IL-4 and IL-7 responsive memory-like CD4(+) T cells. Vaccine 30(12):2140-2145.

Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D, Jr., & Mello CC (2012) CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors. Cell 151(7):1488-1500.

Hu C, Nikolic D, Eggler AL, Mesecar AD, & van Breemen RB (2012) Screening for natural chemoprevention agents that modify human Keap1. Analytical biochemistry 421(1):108-114.

Jennings ME, Quick LN, Ubol N, Shrom S, Dollahon N, & Wilson JW (2012) Characterization of Salmonella type III secretion hyper-activity which results in biofilm-like cell aggregation. PloS one 7(3):e33080.

Kerwin CL & Wykoff DD (2012) De novo generation of a phosphate starvation-regulated promoter in Candida glabrata. FEMS yeast research 12(8):980-989.

Kraut DA, Israeli E, Schrader EK, Patil A, Nakai K, Nanavati D, Inobe T, & Matouschek A (2012) Sequence- and species-dependence of proteasomal processivity. ACS chemical biology 7(8):1444-1453.

Lee HC, Gu W, Shirayama M, Youngman E, Conte D, Jr., & Mello CC (2012) C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell 150(1):78-87.

Liu W, Das A, Morales R, Banday M, Aris V, Lukac DM, Soteropoulos P, Wah DA, Palenchar J, & Bellofatto V (2012) Chromatin immunoprecipitation and microarray analysis reveal that TFIIB occupies the SL RNA gene promoter region in Trypanosoma brucei chromosomes. Molecular and biochemical parasitology 186(2):139-142.

Ott, C. M., A.Crabbé, J. W. Wilson, J. Barrila, S. L. Castro, and C. A. Nickerson. 2012. Microbial stress: spaceflight-induced alterations in microbial virulence and infectious disease risks for the crew. In "Stress Challenges and Immunity in Space", ed. A. Chouker. Springer Press, Inc. Pages 203-226.

Palenchar PM & Palenchar JB (2012) The evolution of metabolic enzymes in Plasmodium and trypanosomatids as compared to Saccharomyces and Schizosaccharomyces. Molecular and biochemical parasitology 184(1):13-19.

Solnoki KW, Sing AH, Sofa CJ, Miller R, Ogorzalek PA, Penek HV, & Palenchar JB (2012) TbENF is an essential TbTFIIB-interacting trypanosomatid-specific factor. Molecular and biochemical parasitology 181(2):94-101.

2011

Crabbe, A., M.J. Schurr, P. Monsieurs, J. Schurr, J.W. Wilson, C.M. Ott, et. al. 2011. Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen. Appl. Environ. Microbiol. 77(4):1221-30

Henry TC, Power JE, Kerwin CL, Mohammed A, Weissman JS, Cameron DM, & Wykoff DD (2011) Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts. Eukaryotic cell 10(2):198-206.

Jennings ME, Quick LN, Soni A, Davis RR, Crosby K, Ott CM, Nickerson CA, and J.W. Wilson. 2011. Characterization of the Salmonella enterica Serovar Typhimurium ydcI Gene, Which Encodes a Conserved DNA Binding Protein Required for Full Acid Stress Resistance. J. Bacteriol. 193(9):2208-17.

Kennedy C, Nelson MD, & Bamezai AK (2011) Analysis of detergent-free lipid rafts isolated from CD4+ T cell line: interaction with antigen presenting cells promotes coalescing of lipid rafts. Cell communication and signaling : CCS 9(1):31.

Middler SL, Gomez S, Parker CD, & Palenchar PM (2011) The effects of combinatorial treatments with stress inducing molecules on growth of E. coli colonies. Current microbiology 63(6):588-595.

Santiago, C. P., L. N. Quick, and J. W. Wilson. 2011. Self-transmissible IncP R995 plasmids with alternative markers and utility for Flp/FRT cloning strategies. J. Microbiol. Biotechnol. 21(11):1123-1126.

Shah TD, Hickey MC, Capasso KE, & Palenchar JB (2011) The characterization of a unique Trypanosoma brucei beta-hydroxybutyrate dehydrogenase. Molecular and biochemical parasitology 179(2):100-106.

2010

Orkwis BR, Davies DL, Kerwin CL, Sanglard D, & Wykoff DD (2010) Novel acid phosphatase in Candida glabrata suggests selective pressure and niche specialization in the phosphate signal transduction pathway. Genetics 186(3):885-895

O'Sullivan, L. E., C. A. Nickerson, and J. W. Wilson. 2010. A series of IncQ-based reporter plasmids for use in a range of Gram negative genera. J. Microbiol. Biotechnol. 20(5):871-874.

Quick, L. N., A. Shah, and J. W. Wilson. 2010. A series of vectors with alternative antibiotic resistance markers for use in lambda Red recombination. J. Microbiol. Biotechnol. 20(4):666-9.

Radtke, A.L., J.W. Wilson, S. Sarker, and C.A. Nickerson. 2010. Analysis of interactions of Salmonella type III secretion mutants with 3-D intestinal epithelial cells. PLoS ONE. 5(12):e15750.

2009

Banerjee H, Palenchar JB, Lukaszewicz M, Bojarska E, Stepinski J, Jemielity J, Guranowski A, Ng S, Wah DA, Darzynkiewicz E, & Bellofatto V (2009) Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins. RNA 15(8):1554-1564.

Ibrahim BS, Kanneganti N, Rieckhof GE, Das A, Laurents DV, Palenchar JB, Bellofatto V, & Wah DA (2009) Structure of the C-terminal domain of transcription factor IIB from Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America 106(32):13242-13247.

Kerwin CL & Wykoff DD (2009) Candida glabrata PHO4 is necessary and sufficient for Pho2-independent transcription of phosphate starvation genes. Genetics 182(2):471-479.

Stomel, J.M., J.W. Wilson, M.A. Leon, P. Stafford, and J.C. Chaput. 2009. A man-made ATP-binding protein evolved independently of nature causes abnormal growth in bacterial cells. PLoS ONE. 4(10):7385.

Timakhov RA, Tan Y, Rao M, Liu Z, Altomare DA, Pei J, Wiest DL, Favorova OO, Knepper JE, & Testa JR (2009) Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice. Genes, chromosomes & cancer 48(9):786-794.

Russo LA, Peano BJ, Trivedi SP, Cavalcanto TD, Olenchock BA, Caruso JA, Smolock AR, Vishnevsky O, & Gardner RM (2009) Regulated expression of matrix metalloproteinases, inflammatory mediators, and endometrial matrix remodeling by 17beta-estradiol in the immature rat uterus. Reproductive biology and endocrinology :RB&E 7:124.

Villanova Biochemistry at a Glance

Degrees Offered: BS

Core Faculty: 14

Undergraduate Majors: 114

Equipment: Complete array of modern instrumentation.

Building:  Mendel Science Center

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